Why SDFC?

Dr. Valerie A. Flores

Dr. Valerie A. Flores - Extended Curriculum Vitae

Education

B.S University of Southern California, Magna Cum Laude (Gerontology) 2008

M.D. Yale University School of Medicine 2012

Career/Academic Appointments

06/2012-06/2016: Resident, Obstetrics and Gynecology, Women and Infants Hospital/Warren Alpert Medical School of Brown University, Providence, RI.

07/2016-06/2019: Fellow, Reproductive Endocrinology and Infertility, Yale University School of Medicine, New Haven, CT.

07/2019-06/2022: Assistant Professor, Yale University School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, New Haven, CT

07/2022-2/2024: Reproductive Endocrinologist and Infertility Specialist, Reproductive Partners Fertility Center- San Diego, CA

10/2022- Present: Clinical Assistant Professor, University of California, San Diego, Health Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, San Diego, CA

2/2023- Present: Assistant Professor Adjunct, Yale University School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, New Haven, CT

2/2024: Reproductive Endocrinologist and Infertility Specialist, San Diego Fertility Center, San Diego, CA

Administrative Positions

07/2017-06/2022: Faculty Advisor, Yale University School of Medicine Ob/Gyn Interest Group

01/2020-06/2022: Diversity, Equity and Inclusion Task Force Leader on Research and Recruitment, Yale University School of Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences

10/2021-10/2022: Vice Chair, Endometriosis Special Interest Group, American Society for Reproductive Medicine

10/2022-10/2023: Chair-Elect, Endometriosis Special Interest Group, American Society for Reproductive Medicine

10/2023-10/2024: Chair, Endometriosis Special Interest Group, American Society for Reproductive Medicine

Teaching and Appointments

01/2015: Warren Alpert Medical School of Brown University SIM event

06/2014-06/2015: Warren Alpert Medical School of Brown University Assistant Clinical Instructor

06/2012-06/2015: Warren Alpert Medical School of Brown University OB Interest Group

10/2009-10/2010: Yale Neighborhood Health Project Coordinator

06/2009-06/2010: Yale Histology Teaching Assistant

Professional Honors & Recognition

International/National/Regional

01/2023: Early Career Investigator Award, Society for Reproductive Investigation
06/2015: Resident Research Award, Women and Infants Hospital
06/2015: Excellence in Teaching Award, Women and Infants Hospital
06/2014: Excellence in Teaching Award, Women and Infants Hospital
05/2008: John R. Hubbard Award, University of Southern California

Committee Service

03/2020: NIH Study Section: Contraceptive Development Program NICHD Contraceptive Clinical Trial Network Female March 2nd-3rd.
07/2021-06/2022: Yale School of Medicine Search Committee: MFM Chair Search.

Past Grants

Agency: Reproductive Scientist Development Program Grant (RSDP)/Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID#: K12 HD000849
Title: The Mechanism of Inflammation-Mediated Progesterone Resistance in Endometriosis
PI: Valerie A. Flores, MD
Percent effort: 75%
Grant Award: $125,000
Project Period: 07/2021-07/2022

Agency: Reproductive Scientist Development Program Grant (RSDP)/Eunice Kennedy Shriver National Institute of Child Health and Human Development
ID#: K12 HD000849, Supplement Grant
Title: The Mechanism of Inflammation-Mediated Progesterone Resistance in Endometriosis
PI: Valerie A. Flores, MD
Percent effort: 75%
Grant Award: $10,000
Project Period: 07/2019-06/30/2021

Agency: SRI/Bayer
ID#: Discovery Grant
Title: “Molecular Targets for Precision Medicine in Endometriosis”
PI: Valerie A. Flores, MD
Percent effort: 99%
Grant Award: $15,000
Project Period: 07/2018- 07/2019

Agency: Bennak-Polan Foundation
Title: “Precision Medicine in Endometriosis”
ID#: Women in Obstetrics and Gynecology
“Utilization of Hormone Receptor Status for Predicting Response to Medical Therapy in Endometriosis”
PI: Valerie A. Flores, MD
Percent effort: 1%
Grant Award: $15,000
Project Period: 10/2018- 10/2019

Agency: Prelude Fertility
ID#: Travel Grant
Grant Award: $1,500
Project Period: 10/2018

Current Clinical Trials

Agency: Eunice Kennedy Shriver National Institute of Child Health & Human Development
I.D.# 1R01HD100336-01
Title: “Pre-IVF treatment with a GnRH antagonist in women with endometriosis - A prospective double-blind placebo-controlled trial (PREGnant)”
PI: Hugh S. Taylor, MD
Percent effort: 1%
Project period: 01/2020 – 01/2025

Invited Speaking Engagements, Presentations, Symposia & Workshops

International/National

10/2023: Flores, VA. Endometriosis and In Vitro Fertilization: Unique considerations in the approach to fertility treatment. Roundtable Discussion. ASRM Annual Meeting, New Orleans, LA.

09/2023: Flores VA. Endometriosis and the Approach to Treatment of EndometriosisRelated Infertility. Canadian Fertility and Andrology Society, Toronto, Canada.

07/2023: Flores VA. Avoiding the Risk of Multiples through Single Embryo Transfer— Healthy babies, One at a time. In Vitro Fertilization and Embryo Transfer Conference, Coronado CA.

06/2023: Flores VA. Noninvasive Methods for the Diagnosis of Endometriosis. MDedge Expert Interview.

10/2022: Flores VA, As-Sanie S. Challenging Cases in Endometriosis and Uterine Fibroids: Addressing Unmet Patient Needs with the GnRH Receptor Antagonists. Medscape CME Program.

06/2022: Flores VA, Johnson S. Non-invasive Diagnosis of Endometriosis. Fertility and Sterility and British Society for Endoscopy Journal Club Global Webinar.

03/2022: Flores VA. Endometriosis and the Mechanisms of Progesterone Resistance. SRI Annual Meeting Endometrium Satellite, Denver, CO.

04/2022: Flores VA. The Role of Epigenetic and Post-translational modifications in Mediating Progesterone Resistance, Pain and Infertility in Endometriosis. SRI Invited Lecture Series, Michigan State University.

12/2021: Flores VA, Morse B. Collaborative Care: Improving Patient Satisfaction and Outcomes in Endometriosis. Medscape Program on Endometriosis.

10/2021: Symposium Moderator: Placing Endometriosis on the Global Health Agenda: a joint World Organization/ASRM Symposium. ASRM Annual Meeting, Baltimore, MD.

10/2021: Flores VA. Using Progesterone Receptor Status for Personalized Endometriosis Treatment. Roundtable Discussion. ASRM Annual Meeting, Baltimore, MD.

07/2020: Flores VA, Taylor HS. Patient, Provider and Caregiver Connection: Individualizing Endometriosis Care to Improve Patient Outcomes. Continuing Medical Education Program on Endometriosis.

03/2020: Symposium Speaker. Experimental Biology Annual Meeting: Etiology, Clinical Presentation and Comorbidities Associated with Endometriosis and the Impact of Environmental Immunotoxicants, San Diego, CA (in person meeting cancelled due to COVID-19).

03/2020: Mini-Symposium Moderator: Role of miRNA’s and Inflammation in the Pathology of Endometriosis. 67th SRI Annual Meeting, Vancouver, Canada (invited but deferred to 2021 due to COVID-19).

05/2016: Flores, VA, Matteson K. PCOS: What you need to know as a General Ob-Gyn. Roundtable Discussion. ACOG Annual Clinical and Scientific Meeting, Washington, D.C.

10/2014: Wheeler C, Flores VA. Pediatric and Adolescent Gynecology Workshop: Tools to Teach Your Residents. ASRM Annual Meeting, Honolulu, HI.

Regional

04/2021: New England Ob/Gyn Society's 91st Annual Meeting, Sturbridge, MA: “Endometriosis: Clinical Challenges and Novel Innovations” (Virtual).

05/2014: Grand Rounds, Providence, RI, Co-presenter: “Salpingectomy for Sterilization: A New Standard of Care.”

Professional Service

Journal Service:

07/2017-09/2022 Reviewer for Reproductive Sciences
01/2020- 09/2022 Reviewer for Fertility and Sterility Reports

Professional Organizations:

07/2017-Present Member, Society of Reproductive Investigation
01/2014-06/2016 Member, New England Fertility Society
01/2013-06/2016 Member, American Association of Gynecologic Laparoscopists
07/2012-Present Member, American Society for Reproductive Medicine
07/2010-Present Member, American College of Obstetrics and Gynecology

Yale University Service:

  • University Committee
    07/2017-07/2021 Member, Medical Education Committee, Yale Obstetrics and Gynecology Residency

  • Medical School Committees
    072018-06/2022 Member, Committee on Status of Women in Medicine, Yale School of Medicine

  • Departmental Committees
    07/2020-06/2022 Member, Yale Women’s Reproductive Health Research (WRHR) Advisory
    Committee, Department of Reproductive Sciences

Public Service

07/2015-07/2016 Rhode Island Free Clinic
07/2011-07/2012 Haven Free Clinic

Bibliography

Peer-Reviewed Manuscripts

  1. Flores VA, Nygaard H, Strittmatter S. Memory impairment, Alzheimer’s disease, and the role of signal transduction mechanisms. Yale University, ProQuest, UMI Dissertation Publishing, 2012.

  2. McCoin ML, Flores VA, Wheeler C, Lopes V, Matteson K. Influence of Clinical History and Demographic Factors on Infertility Patients' Willingness to Participate in Clinical Research. Edorium J Clinical Research 2015;1:1-7.

  3. Flores VA, Browning, K, Robison K. Salpingectomy for Sterilization: A new standard of care. Postgraduate Obstetrics and Gynecology. 2015; 35 (14):1-5.

  4. Flores VA, Taylor HS. The Effect of Menopausal Hormone Therapy on Breast Cancer: Avoiding the Risk. Endocrinology and Metabolism Clinics of North America. Postmenopausal Endocrinology. 2015; 44 (3): 587-602. PMID 26316245

  5. Hill A, Lessey B, Flores VA, Taylor HS. Bazedoxifene/conjugated estrogens in combination with leuprolide for the treatment of endometriosis. Clinical Case Reports. 2018; 6(6); 990-994. PMID: 29881549

  6. Flores VA, Stachenfeld N, Taylor HS. Bazedoxifene-Conjugated Estrogens: A novel therapy for treating Endometriosis. Obstetrics and Gynecology. 2018; 132(2):475–477. PMID: 29995747

  7. Flores VA, Vanhie A, Dang T, Taylor HS. Precision Medicine in Endometriosis: Progesterone Receptor Status in Endometriosis. Journal of Clinical Endocrinology and Metabolism. 2018; 103 (12): 4561-4568. PMID: 30357380

  8. Flores VA, Leone C, Taylor HS, Stachenfeld N. Effects of Bazedoxifene/Conjugated Estrogens on reproductive endocrinology and reproductive tract ultrasonographic appearance in premenopausal women: a preliminary study. Gynecological Endocrinology. 2019; 1-5. PMID: 30668182

  9. Mor A, Zhang M, Esencan E, Simsek B, Nichols-Burns SM, Liu Y, Lo J, Kelk DA, Flores V, Gao XB, Seli E. A step towards the automation of intracytoplasmic sperm injection: real time confirmation of mouse and human oocyte penetration and viability by electrical resistance measurement. Fertil Steril 2020; 234-236. PMID: 31883732

  10. Moustafa S, Burn M, Mamillapalli R, Nematian S, Flores VA, Taylor HS. Accurate diagnosis of endometriosis using serum microRNAs. Am J Obstet Gynecol. 2020; 1-8. PMID: 32165186

  11. Kotlyar A, Mamillapalli R, Flores VA, Taylor HS. Toficitinab Alters Stat3 Signaling and leads to endometriosis and lesion regression. Molecular Human Reproduction. 2021; 1-11. PMID: 33693775

  12. Taylor HS, Li HJ, Carson S, Flores V, Pal L, Robbins J, Santoro NF, Segars JH, Seifer D, Huang H, Young S, Zhang H. Pre-IVF treatment with a GnRH antagonist in women with endometriosis (PREGNANT): study protocol for a prospective, double-blind, placebo-controlled trial. BMJ Open. 2022; 1-6. PMID: 35715184

  13. Siblini H, Al Hendy A, Segars J, Gonzalez F, Taylor HS, Singh B, Flaminia A, Flores VA, Christman G, Huang H, Johnson J, Zhang H. Assessing the Hepatic Safety of Epigallocatechin Gallate (EGCG) in Reproductive-Aged Women. 2023; Accepted.

Chapters, Books, and Reviews

  1. Flores VA, Taylor HS. Future and Current SERMs: An Update. The Female Patient. 2010 May;35(5): 21-24.

  2. Flores VA, Taylor HS. The Effect of Menopausal Hormone Therapy on Breast Cancer: Avoiding the Risk. Endocrinology and Metabolism Clinics of North America. Postmenopausal Endocrinology. 2015;44(3):587-602. PMID: 26316245

  3. Flores, VA, Pal L. Managing Menopause by Combining Evidence with Clinical Judgement. Clinical Obstetrics and Gynecology. 2018; 61(3):496–507. PMID: 29985172

  4. Flores, VA, Taylor HS. Endometriosis. In: Burakoff R, ed. Medicine(online). Toronto, Canada: Decker Medicine, 2019. DOI:10.2310/7900.1005.

  5. Associate contributor, “Speroff’s Clinical Gynecologic Endocrinology and Infertility” 9th Edition, Wolters Kluwer, Philadelphia, PA, USA. Hugh S. Taylor, Lubna Pal, Emre Seli, eds. 2020.

  6. Taylor HS, Kotlyar A, Flores VA. Endometriosis is a Chronic Systemic Disease: Clinical Challenges and Novel Innovations. Lancet 2021;397(10276):839-852. PMID: 33640070

  7. Flores VA, Pal L, Manson JE. Hormone Therapy in Menopause: Concepts, Controversies & Approach to Treatment of Menopausal Symptoms. Endocrine Reviews 2021; PMID: 33858012

  8. Flores VA, Manson JE. Patterns of menstrual cycle length over the menopause transition—a novel marker for cardiovascular risk? Menopause (editorial) 2022; 29 (1) PMID: 34873104

Abstract

2023: Flores VA. Endometriosis and In Vitro Fertilization: Unique considerations in the approach to fertility treatment. Roundtable ASRM Annual Meeting, New Orleans, LA

2023: Flores VA, Wang X, Grechukhina O, Grechukhina V, Taylor HS. SUMOylation Mediates Progesterone Resistance in Endometriosis Treatment Failure and Endometriosis Related Infertility. SRI Annual Meeting, Brisbane, Australia.

2022: Flores VA, Wang X, Taylor HS. SUMOylation Mediates Progesterone Resistance in Endometriosis Treatment Failure and Impaired Implantation. ASRM Annual Meeting, Anaheim CA.

2022: Flores VA, Wang X, Taylor HS. Progesterone Resistance and Altered Estradiol Responsiveness in Endometriosis. SRI Annual Meeting, Denver CO.

2021: Flores VA, Dang T, Taylor HS. Flores VA, Dang T, Taylor HS. ARID1a Involvement in Endometriosis Disease Progression. ASRM Annual Meeting, Baltimore MD.

2021: Flores VA, Dang T, Taylor HS. The Role of ARID1a in Mediating Endometriosis Disease Progression. SRI Annual Meeting, Boston MA.

2020: Flores VA, Sahin C, Taylor HS. Murine Avatars for Precision Medicine in Endometriosis. 76th ASRM Scientific Congress and Expo, Virtual Meeting.

2020: Kotlyar A, Mamillapalli R, Flores VA, Taylor HS. Tofacitinib alters STAT3 signaling and leads to endometriosis and lesion regression. 76th ASRM Scientific Congress and Expo, Virtual Meeting.

2020: Flores VA, Kelk D, Bjorkman S, Kodaman, PH. Impact of Endometrial Pattern on Live Birth Rate and Subsequent Development of Hypertensive Disorders of Pregnancy. 76th ASRM Scientific Congress and Expo, Virtual Meeting.

2020: Flores VA, Dang T, Huttler J, Taylor HS. The Role of Estrogen Receptor Alpha in Mediating Progesterone Resistance and Disease Progression in Endometriosis. 67th SRI Annual Meeting, Vancouver, Canada (cancelled due to COVID-19)

2019: Flores VA, Chen P, Huttler J, Zhou Y, Dang T, Mamillapalli R, Taylor HS. NFB2 Expression in Endometriosis is Regulated by miRNA Let-7b. 75th ASRM Scientific Congress and Expo, Philadelphia, PA.

2019: Flores VA, Dang T, Huttler J, Taylor HS. Paradoxical decrease of ER beta in Treatment Resistant Endometriosis. 66th SRI Annual Meeting, Paris, France.

2019: Flores VA, Bjorkman S, Kelk D, Kodaman N, Kodaman PH. Trilaminar Endometrial Pattern Predicts Live Birth Rates in Frozen Embryo Transfer Cycles. 66th SRI Annual Meeting, Paris, France.

2018: Flores VA, Vanhie A, Dang T, Taylor HS. Progesterone Receptor Status as a Predictor of Response to Progestins in Endometriosis. ASRM Scientific Congress and Expo, Denver, CO.

2018: Margulies S, Flores VA, Parkash V, Pal L. An Interdisciplinary Approach to Improving the Understanding of Diagnostic and Management Dilemmas Surrounding Chronic Endometritis ASRM Scientific Congress and Expo, Denver, CO.

2018: Flores VA, Vanhie A, Dang T, Taylor HS. Precision Medicine in Endometriosis: Progesterone Receptor Status Predicts Progestin Response. Poster Presentation. 65th SRI Annual Meeting, San Diego, CA.

2017: Moustafa S, Burn M, Flores,VA, Nematian S, Cosar E, Taylor HS. Serum microRNAs used to diagnose endometriosis prior to surgical diagnosis: a prospective study. Oral Presentation. ASRM Scientific Congress and Expo, San Antonio, TX.

2017: Flores VA, Kelk D, Kodaman PH. Trilaminar Endometrial Pattern Correlates with Higher Clinical Pregnancy Rates in Frozen Embyro Transfer Cycles. Poster Presentation. ASRM Scientific Congress and Expo, San Antonio, TX.

2013: Flores VA, Snigovskikh V, Frishman G. Isolated Longitudinal Vaginal Septum. Video Presentation. AAGL 42nd Global Conference, Washington, D.C.

2013: Snigovskikh V, Flores VA, Frishman G. Transvaginal Ultrasound Guided Sclerosis of Endometriomas. Video Presentation. AAGL 42nd Global Conference, Washington, D.C.

2013: Flores VA, Underhill L., Krueger, P. M., Robins J. C. A Novel 3-Dimensional (3D) Cell Culture for the Study of Trophoblast Differentiation, Behavior, and Invasion. Oral Presentation. Conjoint Annual Meeting IFSS/ASRM, Boston, MA,

2013: Flores VA, Snigovskikh V, Frishman G. Isolated Longitudinal Vaginal Septum. Video Presentation. Conjoint Annual Meeting IFSS/ASRM, Boston, MA.

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