Preimplantation genetic diagnosis (PGD) is a technique that can be used in conjunction with IVF to test embryos for genetic disorders prior to their transfer to the uterus. PGD makes it possible for couples with serious inherited disorders to decrease the risk of having an affected child. PGD also can be considered for couples experiencing repeat pregnancy loss due to genetic disorders, couples that already have one child with a genetic disorder and are at high risk of having another, and couples interested in family balancing.
PGD is performed using a high-powered microscope. A single cell is removed from each embryo on day three of development and tested for the genetic trait of interest. The unaffected embryos are identified, separated from the affected embryos, and transferred into the uterus.
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